Brain GLP-1 and insulin sensitivity
نویسندگان
چکیده
منابع مشابه
Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ
OBJECTIVE Glucagon-like peptide 1 (GLP-1) is a gut-brain hormone that regulates food intake, energy metabolism, and cardiovascular functions. In the brain, through a currently unknown molecular mechanism, it simultaneously reduces femoral artery blood flow and muscle glucose uptake. By analogy to pancreatic β-cells where GLP-1 activates protein kinase C (PKC) to stimulate insulin secretion, we ...
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We examined the dose-related net effects of glucagon-like peptide 1 (GLP-1) on insulin secretion, insulin sensitivity, and glucose disposal as derived from the minimal model of glucose disappearance in anesthetized mice. GLP-1 dose dependently potentiated insulin secretion after glucose administration, with the half-maximal effect at 1 nmol/kg. GLP-1 also dose dependently reduced the area under...
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OBJECTIVE Glucagon-like peptides are co-released from enteroendocrine L cells in the gut and preproglucagon (PPG) neurons in the brainstem. PPG-derived GLP-1/2 are probably key neuroendocrine signals for the control of energy balance and glucose homeostasis. The objective of this study was to determine whether activation of PPG neurons per se modulates glucose homeostasis and insulin sensitivit...
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Glucagon-like peptide-1 (GLP-1)-based incretin therapy is becoming central to the treatment of type 2 diabetes. Activation of incretin hormone receptors results in rapid elevation of cAMP followed by enhanced insulin secretion. However, the incretin effect may be significantly impaired in diabetes. The objective of this study is to investigate downregulation of GLP-1 signaling by small ubiquiti...
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Introdution: The purpose of this study was to investigate the effect of twelve weeks of combined exercise with two patterns (aerobic-resistance and resistance-aerobic) on GLP-1 and insulin resistance in women with type 2 diabetes. Methods: In this practical and semi-experimental study, 42 women with type 2 diabetes were divided into three groups: aerobic-resistance group (n=15), resistance-aer...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2015
ISSN: 0303-7207
DOI: 10.1016/j.mce.2015.02.017